This might be a long post, but I beleive worth the read especially for those like crnkr and sstorm who tried Zelnorm, but it didn't work. I am 6 weeks into the clinical study for Zelnorm. I have always been pretty sure I got the actual drug and not a placebo, because it "helped" me a little, but definitely not as much as I had hoped. Although over the past couple of weeks it didn't seem to be helping at all so I started thinking maybe I did get the placebo. Anyway the instructions I received were to take it one half hour before breakfast and one half hour before dinner (which I have done faithfully) However 3 days ago, not having the liberty to play around with dosage, I decided to change the "time" in which I take it and I am hoping it is not a fluke, but the results have been amazing. I usually don't eat breakfast until I get to work at 9:00 a.m., so I was taking the Z at 8:30 before I left my house. However 3 days ago I decided to take it immediately upon getting up in the morning at 6:00 a.m. followed by my usual 2 cups of coffee. Since changing times, by 7:00 or 7:30 a.m., I have been "running" to the toilet and I "go" at least 3 times..sometimes more!I still don't eat my breakfast until 9:00 when I get to work and I have found I usually have to "go" again around 10:00 or 10:30.I have also been taking my evening does at least 2 hours before dinner instead of a half hour before and I have been "going" again before bed. Granted, the stool is rather soft, but not really "D", but being a true "C" person soft stool or even "D" doesn't bother me at all. I really feel if I could play around with dosage things would be even better. I don't know if I am on the 4 milligram dose or the 12 milligram. In any case, I urge those of you who have said the Z doesn't help you to try it on an empty stomach at least 2 or 3 hours before eating instead of the half hour before and see if it makes a difference. Good Luck. I just hope it keeps working for me, because I am actually starting to feel better!