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There is a place where the large intestine bends about that spot. It seems to be sensitive for many of us. It doesn't particularly bother me when exercising--elliptical trainer and distance biking--but I get it when driving distances. Something about the angle of my lower body in the bucket seat, I think.I have treated most of my symptoms for many years with a flavonoid supplement developed for cardiovascular health. The last real problem seems to be flatulence. Probiotics seem to have helped, some; but certainly haven't eliminated it. Recently, my wife and I have been experimenting with the Eating 4 Your Blood Type diet and the frequency and pungency of the gas has decreased markedly. It certainly makes for a much pleasanter sleeping experience.Mark