Our poor confuse Tal, who is clearly not up to date on IBS research.This is from 97, since then they have found it is not a biological marker IN ALL IBSErs.although when this was posted, it was thought it maybe one.Now they know somewhere between 80 to 90 percent have rectal hypersensitvity.They also thought the brain activation was also, but the jury is still out on that.Breakthroughs in IBS research."By using sophisticated imaging techniques that allow us to visualize the activity of the living human brain (see ï¿½Looking Into the Living Human Brainï¿½), researchers at the UCLA Neuroenteric Disease Section have recently identified for the first time the regions within the brain that are involved in the perception and modulation of visceral sensations, including visceral pain. In addition, by comparing brain responses to an acute intestinal stimulus between healthy control subjects, patients suffering from IBS, and patients with ulcerative colitis, they were able to identify specific alterations in how the brains of IBS patients process and respond to acute colonic pain. These research results have recently been published in Gastroenterology. This is the first study which has been able to identify an objective biological marker that is only seen in IBS patients and that is located within brain regions, which are likely to be involved in the alterations in perception and autonomic responses that underlie the most common IBS symptoms. These findings are the first step in a better understanding of how these symptoms develop and how we can treat them by identifying specific targets for pharmacological therapy. The most prominent brain region found to be activated in response to intestinal stimulation in healthy subjects was a specific area within the anterior cingulate cortex which forms part of the limbic system. The limbic system, which has also been referred to as the ï¿½visceral cortexï¿½ plays a prominent role in a wide range of functionsï¿½from maintaining homeostasis, to autonomic control of the digestive system, to pain perception to the generation of feelings and emotions, and to memory of past emotional states. The specific area within the anterior cingulate cortex identified in the brain imaging studies plays a prominent role in several aspects relevant to IBS symptoms: 1. It is the ï¿½executive areaï¿½ in the regulation of colonic motility and water absorption which in turn determines the frequency and consistency of bowel movements. 2. It is part of the medial pain system which determines the affective component (i.e. the degree of suffering or unpleasantness) associated with pain perception. Specific regions with the medial pain system play an important role in suppressing the perception of pain by releasing endorphin molecules (the bodyï¿½s own painkillers), while other regions participate in the memory formation of past painful experiences. 3. The brain region identified by the UCLA researchers plays a prominent role in the regulation of maternal behaviors and is crucial for mediating communication between newborns and their mother. The results of this study have wide ranging implications for all patients suffering from IBS. The findings for the first time have established IBS as a biological disorder, which can no longer be labeled psychological or ï¿½not realï¿½ by the healthcare system. The current results are the basis for future research efforts delineating the networks and receptors within the brain that are responsible for such IBS symptoms as abdominal pain and discomfort, sleep disturbance, and altered bowel habits. A range of brain imaging studies are currently underway at UCLA which aim at unraveling these mechanisms. Brain regions and receptor systems identified by functional brain imaging studies are likely to become targets for new drug developments in the near future. " http://www.cns.med.ucla.edu/Articles/Patie...eakthroughs.htm although when this was posted, it was thought it maybe one.Now they know somewhere between 80 to 90 percent have rectal hypersensitvity.To date no biological marker has been found in all IBSers.Nor is rectal hypersensitvity even cosistent with Dysbiosis.Nor is incomplete evacuation.and just fyi, they use HT to study this.Gut. 2002 Nov;51(5):701-4. Related Articles, Links Visceral sensation and emotion: a study using hypnosis.Houghton LA, Calvert EL, Jackson NA, Cooper P, Whorwell PJ.Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK. lahoughton###man.ac.ukBACKGROUND AND OBJECTIVES: We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to investigate the effect of hypnotically induced emotion on the visceral sensitivity of the gut. METHODS: Sensory responses to balloon distension of the rectum and compliance were assessed in 20 patients with irritable bowel syndrome (IBS) (aged 17-64 years; 17 female) diagnosed by the Rome I criteria. Patients were studied on four separate occasions in random order either awake (control) or in hypnosis, during which anger, happiness, or relaxation (neutral emotion) were induced. RESULTS: Hypnotic relaxation increased the distension volume required to induce discomfort (p=0.05) while anger reduced this threshold compared with relaxation (p0.05), happiness (p0.01), and awake conditions (p0.001). Happiness did not further alter sensitivity from that observed during relaxation. There were no associated changes in rectal compliance or wall tension. CONCLUSIONS: Further to our previous observations on motility, this study shows that emotion can also affect an IBS patient's perception of rectal distension and demonstrates the critical role of the mind in modulating gastrointestinal physiology. These results emphasise how awareness of the emotional state of the patient is important when either measuring visceral sensitivity or treating IBS.Publication Types: Clinical Trial Randomized Controlled Trial PMID: 12377810FACT!!!!!!!!!!!!!!!!!!!!!!!!!!!! To date no biological marker has been found in all IBSers. You need to do more studing, you have no idea what your talking about, that twice today, you have been very wrong.