I have IBS-D and have tried several Rx's. I have tried Reglan, Bentyl,Lotronex, Cholestyramine, Equalactin(OTC), Buspar and now I'm on Amitriptyline, Prilosec and calcium. The whole thing is that it's different for each person and you need to try different drugs and combinations. Don't give up if the first med you are put on doesn't work. Good luck.