Hi all,I posted this over on the Lotronex board, but thought I might get more response over here.I've been reading a bunch of posts here & on the main IBS board about all different kinds of anti-anxiety/depression medication, ones that are closest to Lotronex - Remeron, Zofran, Xanax, etc.Here's my symptoms, I'm hoping someone has the same and has tried something that's worked! I used Lotronex, and it was Great for me, absolutely No Problems whatsoever. It started working for me right away. And, I only had to take 1/2 a pill every other day. When I first got IBS many years ago, I used to be D, and on the thin side. Now, in the last 2-3 years or so, I've gained unwanted weight, I'm more inconsistent, not really D (only have that once in awhile) and rarely ever C. But, I do have a lot of fear of going places far, or with only 1 or 2 toilets, etc. Not really an axiety attack, but I worry about it and the fear of something happening prevents me from going places & doing things.Immodium is great to stop attacks after they start, and it works pretty quick for me, but what was great about Lotronex is that it was Preventative, consistently.So I'm looking to see which medication I can ask my gastro doctor for specifically. I'd like to just be more "normal" (I know, wouldn't everyone here), as in regualar BM's on a daily basis, and not have the fear/concern of something happening unexpectedly. I've read that Remeron is pretty close/good, but that it cause either weight gain or increased appetite - I definitely don't want either of that!Then I've read about Zofron, but on the webmd.com, it says it's mostly for Nausea.Also, I tend to be on the lazy/tired side lately, so anything with a side effect of drowsiness, I don't want either. So what is all of your suggestions?Thanx!