Very interesting response. I've been on Prozac for years for OCD and depression. Never noticed that My IBS was worse. On Elavil my IBS was helped because of it's side effect of causing constipation and for me controlled D. I was on Elavil (a tryclyclic) for depression only. And yes coming off any antidepressant must be a very slow decrease taking months depending on the dose. I wonder if others would agree with the response. I think it's more complicated than she states. Not all antidepressants work the same way. Remeron is said to be great for depression, good sleep, weight gain unless you exercise, and great for IBS. Look for posts by "Guy" on the IBS BB (the search function there is not working, or maybe it is).I'm not sure taking meds is OK every other day, check with a Doctor. I have cut pills in half or used half of capsule contants without a doctors telling me to, but saying it was O.K. and didn't think it really mattered, but I did!vikee