I experienced the same thing - my symptoms grew worse over time on Protonix. I discussed this with my pharmacist and he recommended trying something different, such as going to the health food store and getting a strong probiotic and digestive enzymes. If you try the Aciphex and are still having trouble, definitely have the endoscopy done to rule out any serious problems. I had to have a second endoscopy done last summer because I had an episode of painful swallowing. Nothing was found other than mild inflammation but at least it ruled a few things out. If you do have the endoscopy, ask the doctor to do a biopsy for eosinophilic esophagitus. This is an allergic inflammation of the esphagus that does not respond to PPIs. I suspect this may be what is wrong with me.