I've been struggling with IBS-D for over 20 years now along with the usual severe pain and cramping. However, never once in those years have I been awaken by pain or cramps once I fall asleep at night. If I awake briefly during the night there is no pain. When I first get up in the morning there is no pain right away then until I've been awake an hour or so and the whole day of cramps starts all over again. Anyone here have the same experience? And if so has a doctor given you an explanation for this? I just can't help but think that the answers to this question may contain answers to the whole unsolved mystery of the cause of IBS. Thanks in advance for your help.