Irritable Bowel Syndrome and Digestive Health Support Forum banner
1 - 5 of 5 Posts

·
Banned
Joined
·
5,767 Posts
Discussion Starter · #1 ·
one piece of the puzzle found, but the research doesn't tell me how to fix it?1: Am J Gastroenterol 2002 Mar;97(3):654-61 Related Articles, Books, LinkOut Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study.Bonaz B, Baciu M, Papillon E, Bost R, Gueddah N, Le Bas JF, Fournet J, Segebarth C.Departement d'Hepato-Gastroenterologie, CHU, Grenoble, France.OBJECTIVES: In healthy subjects, the neural correlates of visceral pain bear much similarity with the correlates of somatic pain. In patients with irritable bowel syndrome, the central nervous system is believed to play a strong modulatory or etiological role in the pathophysiology of the disease. We hypothesize that this role must be reflected in aberrations of central functional responses to noxious visceral stimulation in these patients. To verify this hypothesis, we have induced transient rectal pain in patients and assessed the functional responses of the brain by means of functional magnetic resonance imaging. METHODS: Twelve right-handed patients (11 female) were examined. Functional imaging (1.5 T) was performed following a block paradigm, alternating epochs with and without noxious stimulation of the rectum. Rectal pain was induced by inflating a latex balloon. Whole-brain coverage was achieved by means of echo-planar magnetic resonance acquisition. RESULTS: A strong variability of the individual responses to rectal pain was found in patients with irritable bowel syndrome. Significant activations were found in only two patients, and group analysis did not reveal significant activations. In contrast, all patients exhibited significant deactivations. Group analysis revealed significant deactivations within the right insula, the right amygdala, and the right striatum. CONCLUSIONS: This study reveals aberrant functional responses to noxious rectal stimulation in patients with irritable bowel syndrome. Those results add grounds to the hypothesis that the central nervous system plays a significant role in the pathophysiology of this syndrome.tom
 

·
Registered
Joined
·
1,293 Posts
I think they should do a test like that with people with sunburn. Take control subjects and people with bad sunburns, hook them up to a mri, then slap the subjects and see how the brain responds. My hypothesis is people with sunburns will feel more pain than healthy controls.
 

·
Registered
Joined
·
1,293 Posts
I think they should do a test like that with people with sunburn. Take control subjects and people with bad sunburns, hook them up to a mri, then slap the subjects and see how the brain responds. My hypothesis is people with sunburns will feel more pain than healthy controls.
 

·
Registered
Joined
·
23,983 Posts
Actually for the most part IBS is faulty signals.And funny you should mention sunburn, because in a way you can compare that to the nerve lining in the intestines in IBS. ITs like suburn, or sensitive cells lining the gi tract that are effected by pressure.This is another CONFIRMATION the IBS is a brain gut dysfunction!!!!!!!!!!!!!
 

·
Registered
Joined
·
23,983 Posts
Actually for the most part IBS is faulty signals.And funny you should mention sunburn, because in a way you can compare that to the nerve lining in the intestines in IBS. ITs like suburn, or sensitive cells lining the gi tract that are effected by pressure.This is another CONFIRMATION the IBS is a brain gut dysfunction!!!!!!!!!!!!!
 
1 - 5 of 5 Posts
This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.
Top