Funny, I took Prilosec(before it was OTC), Prevacid, and Nexium.. Prescribed by my PCP because he knew nothing about IBS... This was before I was referred to a GI 6 years ago. At that time I had already gone on a 6mnth course of tetracycline.3 years later, I went on a year long course of doxycycline.I'm still not sure if c.diff would still be present after 2 and a half years of not being on an antibiotic.I don't think it would be.