Well, as you know.. it's going to destroy the time release mechanism of the drug.Basically, if you were taking 25mgCR of Paxil, it would release it pretty much all at once... Would that kill you? Probably not. But you might experience more side-effects with it.Xanax XR... Probably the same thing if you're tolerant on it. I was taking .5mg of the regular Xanax, but moved to Xanax XR just so it would last longer and I'd get more coverage. If I cut the Xanax XR .5mg in half, it wouldn't have made a difference if it was all released at once, because I was already taking .5mg of Xanax. The problem is when you're not tolerant of the medicine and you cut, break, or crush the pill and it all gets released at once; that's when you seriously risk overdose. This might not happen with the anti-depressants, but it's very common in pain medications like OxyContin. They have 10mg, 20mg, 40mg, 80mg, and 160mg pills that are control-released. If anyone crushed up OxyContin that wasn't tolerant to the medicine (mainly the 40mg, 80mg, or 160mg pill--but it's not good to do it at all, obviously!) and took it however they decided to, they risk overdose, because it's releasing WAYYYYYY too much medicine at once... way way way too much! They actually discontinued their 160mg pill for awhile when OxyContin was getting a lot of bad press (it's eased up some); they just recently started manufacturing it again.It all depends on the medication, the person, if their tolerant, and that kind of thing.The CR's, XR's, and SA's weren't made to be cut or broken, but there are *some* instances where it wouldn't hurt you,like the example of me and the .5mg regular Xanax and the .5mg Xanax XR.Man, I rambled.. Haha, sorry!