I tried Zelnorm back in 2002 and it didn't work for me. It made me have bad stomach cramps and massive bloating. Since then I have dealt with my ibs on my own and had a hysterectomy in September of 06. My new GI doc wants to try new meds and put me back on Zelnorm to give it another try. I started on 6mg 2x a day with not much change except massive nausea for about 2 hours after I take it. I cut back to 3mg 2x a day and feel a little better but still have the nausea. Anyone else experience the nausea? The reason I ask is because I have a few other medical mysteries that haven't been solved since my surgery - chest pain and numbness in left arm and under left breast. I have been tested and poked and proded for months and am currently taking a break from all the doctors.