My doctor just changed my zoloft to 75mg instead of 50. But I take one 50 in the morning then a 25 at night. I would think that a 75 in the am would be better. The only reason I question her is because she drags her feet about the IBS subject and didnt really wanna give me the zoloft (for anxiety) but her assistant did. So my question is for those taking more than the 50mg, do you take you total dose in the am or split like me?